This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Relationship to Increased Blood Viscosity

William I. Rosenblum, MD; Richard M. Asofsky, MD

Arch Neurol. 1968;18(2):151-159.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE natural history of human macroglobulinemia includes transient neurological symptoms ranging from headache to dizziness, dysequilibria, and focal motor weakness.^1-3 In many cases these symptoms are associated with a rise in serum viscosity and are ameliorated by plasmaphoresis which reduces the concentration of macroglobulin (IgM) and the serum viscosity. These symptoms form a portion of the "hyperviscosity syndrome"¹ and are often accompanied by "beading" or the presence of "box-car" deformities in retinal vessels.^1,4-6 An experimental model of macroglobulinemia is provided by Balb/c mice, bearing a plasma cell tumor, (MOPC-104E), which secretes large amounts of IgM into the blood stream.^7,8 Like their human counterparts^1,9,10 these mice display an elevated blood viscosity which is a function of the concentration of IgM in the plasma, and which also depends upon the viscosity of the plasma, and the hematocrit level.⁸ Erythrocytes from these mice displayed a marked . . . [Full Text PDF of this Article]

Author Affiliations
Bethesda, Md

From Laboratory of Neuropathology, National Institute of Neurological Diseases and Blindness (Dr. Rosenblum); and Laboratory of Germfree Animal Research, National Institute of Allergy and Infectious Diseases (Dr. Asofsky), Bethesda, Md.

Footnotes
Submitted for publication July 21, 1967; accepted Aug 14.

Read in part before the annual meeting of the American Association of Neuropathologists, Atlantic City, NJ, June 10, 1967.

Reprint requests to Room 113, Bldg 9, National Institutes of Health, Bethesda, Md 20014 (Dr. Rosenblum).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?