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Systemic Effects of Meningococcal Endotoxin Within the Cerebrospinal Fluid

CPT Thomas B. Ducker, MC, USAR; CPT Richard L. Simmons, MC, USAR

Arch Neurol. 1968;18(2):123-128.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

EVIDENCE has accumulated which suggests that gram-negative endotoxin may act on elements of the nervous system to produce significant systemic pathology.^1-7 Penner and Bernheim⁴ demonstrated that ulcerative lesions of the gastrointestinal tract, which are present in systemic canine endotoxin shock, appear after the introduction of very small doses of Shigella endotoxin into the third ventricle. Such doses would be completely ineffective if given systemically.⁴ Palmerio et al⁵ have confirmed these observations in the dog and rabbit with Escherichia coli endotoxin. Kass et al⁷ observed that the lethal dose of E coli endotoxin is smaller when injected into the carotid artery of rats and that endotoxin lethality can be eliminated by posterior hypothalamic ablation.

We have previously demonstrated that small doses of E coli endotoxin placed into the cisterna magna or lateral ventricle of dogs can produce a variety of systemic pathologic lesions associated . . . [Full Text PDF of this Article]

Author Affiliations
Washington, DC

From the Division of Surgery, Walter Reed Army Institute of Research, Washington, DC.

Footnotes
Submitted for publication Aug 14, 1967; accepted Oct 6.

Reprint requests to Division of Surgery, Walter Reed Army Institute of Research, Washington, DC 20012 (Dr. Ducker).

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