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S. Ahmad Shafiq, PhD; Ade T. Milhorat, MD; Michael A. Gorycki, MS

Arch Neurol. 1967;17(6):666-671.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

RECENTLY, two reports have been published on myopathies characterized primarily by abnormalities of mitochondria. In the first, Luft et al¹ described a severely hypermetabolic patient with loosely coupled oxidative phosphorylation in mitochondria and, in the second, Shy et al² described pleoconial and megaconial conditions, both related to aberrent mitochondria. In Luft's patient as well as in the one with megaconial myopathy, the mitochondria in the muscle fibers were unusually large and contained striking paracrystalline inclusions. This paper reports on four patients with similar mitochondrial changes and discusses the significance of this lesion.

Report of Cases

In the four patients in our study, a diagnosis of either dermatomyositis, polymyositis, nephritis, or spinal muscular atrophy had been made. Each diagnosis was based on physical examination, electromyography, biopsy findings, and laboratory data. Brief summaries are given below.

Case 1.—

This 48-year-old man was found at 43 to have grossly elevated levels . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Institute for Muscle Disease, Inc, New York.

Footnotes
Submitted for publication May 29, 1967; accepted June 28.

Reprint requests to Institute for Muscle Disease, Inc., 515 E 71st St, New York 10021 (Dr. Shafiq).

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