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C. L. Mitchell, PhD; W. W. Kaelber, MD

Arch Neurol. 1967;17(6):653-660.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

URABE and Tsubokawa¹ investigated the effect of unilateral vs bilateral lesions in the centrum medianum in human subjects suffering from intractable pain. They observed that if the pain was well localized and exhibited laterality, then unilateral lesions (placed contralateral to the site of the reported pain) were effective in providing relief. In contrast, if the pain was diffuse and had no laterality, then bilateral lesions were necessary in order to provide pain relief.

In a previous report² we have stated that lesions in or about the nucleus parafascicularis (Pf), centrum medianum (CM), and other contiguous thalamic nuclei were effective in abolishing an escape reaction elicited by stimulation of the tooth pulp in the cat. However, in this study all lesions were made bilaterally.

In view of the report by Urabe and Tsubokawa,¹ it seemed that a comparison of the effect of unilateral vs bilateral lesions on . . . [Full Text PDF of this Article]

Author Affiliations
Iowa City

From the Department of Pharmacology and the departments of anatomy and neurology, College of Medicine, University of Iowa, Iowa City.

Footnotes
Submitted for publication June 19, 1967; accepted June 30.

Read in part before the 79th session of the American Association of Anatomists, San Francisco, April 6, 1966.

Reprint requests to 829 14th Ave, Coralville, Iowa 52240 (Dr. Mitchell).

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