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Robert W. P. Cutler, MD; Gordon V. Watters, MD; John P. Hammerstad, MD; Ezio Merler, PhD

Arch Neurol. 1967;17(6):620-628.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

ONE of the characteristic features of subacute sclerosing leukoencephalitis (SSLE) is a prominent elevation of cerebrospinal fluid (CSF) -globulin concentration.¹ In this study we have attempted to define the origin of the excess -globulin in the CSF. The exchange of gamma G globulin (IgG) labeled with radioactive iodine (¹²⁵I) between the serum and CSF has been examined in two patients with SSLE and in three control subjects with normal CSF lin concentrations. In addition, the rate of flux of -globulin into the CSF was measured during ventriculolumbar perfusion of chemotherapeutic agents. Methotrexate was administered by the intraventricular route to two patients with pontine gliomas, and 5-iododeoxyuridine (IUDR) was administered to two patients with SSLE in an attempt to modify the course of these generally fatal diseases. Results were obtained which suggest that immunoglobulin is synthesized within the nervous system in SSLE.

Report of Cases

CASE 1.—This . . . [Full Text PDF of this Article]

Author Affiliations
Boston

From the Children's Hospital-Peter Bent Brigham Unit of the Department of Neurology (Drs. Cutler, Watters, and Hammerstad) and the Immunology Division of the Children's Hospital Medical Center, (Dr. Merler), Harvard Medical School, Boston.

Footnotes
Submitted for publication July 6, 1967; accepted July 24.

Read before the 92nd annual meeting of the American Neurological Association, Atlantic City, NJ, June 14, 1967.

Reprint requests to Department of Neurology, Children's Hospital Medical Center, 300 Longwood Ave, Boston 02115 (Dr. Cutler).

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