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Neuronal Trophic FunctionA New Aspect Demonstrated Histochemically in Developing Soleus Muscle
G. Karpati, MD;
W. K. Engel, MD
Arch Neurol. 1967;17(5):542-545.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE neuronal trophic influence on developing skeletal muscle fibers has been the subject of speculation in attempts to understand the pathogenesis of certain congenital neuromuscular disorders, such as infantile spinal muscular atrophy1 and central core disease.2 Because direct evidence on the dynamics of the nerve-muscle relationship is impossible to obtain in the human, experimental animals must be used. The sequence of histochemical changes from a mixed to a uniform pattern in the guinea pig soleus extrafusal muscle fibers from the 50th gestational day to 6 weeks postnatal age and prevention of that change by neonatal denervation are described in this study. The developing soleus muscle of the rat and cat was also studied.
Methods
On fresh, frozen, cryostat sections of 10µ thickness, a battery of ten histochemical reactions was used as detailed elsewhere.3,4 Our preferred technique for histochemical fiber typing is the myofibrillar adenosine triphosphatase (ATPase)
. . . [Full Text PDF of this Article]
Author Affiliations
Bethesda, Md
From the Medical Neurology Branch, National Institute of Neurological Diseases and Blindness, Bethesda, Md. Dr. Karpati is a postdoctorate research fellow for the Muscular Dystrophy Association of Canada. His current address is Montreal Neurological Institute, Montreal, Quebec, Canada.
Footnotes
Submitted for publication May 26, 1967; accepted June 16.
Reprint requests to Medical Neurology Branch, National Institute of Neurological Diseases and Blindness, Bethesda, Md 20014 (Dr. Engel).
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