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Intracerebral Hodgkin's Granuloma

David Sohn, MD; Quentin Valensi, MD; Sherwood P. Miller, MD

Arch Neurol. 1967;17(4):429-436.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT is rare for intracerebral Hodgkin's disease to involve cranial nerves, particularly the optic nerves and optic chiasm. Virtually all reported cases of intracerebral Hodgkin's disease initially involved the floor of the cranial cavity and overlying meninges, with secondary extension to cranial nerves and brain. The patient described here with generalized Hodgkin's disease appears unique because the Hodgkin's granuloma originated in the hypothalamus and extended to the optic chiasm and cranial nerves. Clinical features included diabetes insipidus, hallucinations, and peripheral neuropathy. The systemic lesions spared many of the organs usually affected and involved other organs which are usually spared.

Report of a Case

This 23-year-old woman had been well until July 1964 when she developed a superior vena cava syndrome. Thoracotomy was performed at another hospital, with subtotal resection of an anterior superior mediastinal tumor, diagnosed as carcinoma of the thymus. Cobalt irradiation to the mediastinum and neck . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the departments of pathology and medicine, the Maimonides Medical Center, Brooklyn, New York.

Footnotes
Submitted for publication April 15, 1967; accepted June 16.

Repint requests to the Department of Pathology, New York Medical College Center for Chronic Diseases, Bird S. Coler Hospital, Welfare Island, New York 10017 (Dr. Sohn).

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