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III. The Effects of Brain Stem Lesions

M. N. Shalit, MD; O. M. Reinmuth, MD; S. Shimojyo, MD; P. Scheinberg, MD

Arch Neurol. 1967;17(4):342-353.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IT has been known for a long time that changes in cerebral metabolic activity, whether localized or generalized, are followed by concomitant changes in the blood flow. In 1890, Roy and Sherrington¹ concluded from their experiments that... the chemical products of cerebral metabolism contained in the lymph which bathes the walls of the arterioles of the brain can cause variations of the calibre of the cerebral vessels: in this reaction the brain possesses an intrinsic mechanism by which its vascular supply can be varied locally in correspondence with local variations of functional activity.

Many other studies have supported their conclusions. Increases in total brain metabolism produced pentylenetetrazol (Metrazol) administration^2-6 or stimulation of the reticular-activating system in the brain stem (RAS)^7-15 were followed by an increased cerebral blood flow (CBF). Activation of specific parts of the brain by afferent stimulation was followed by local vasodilatation and increase . . . [Full Text PDF of this Article]

Author Affiliations
Miami, Fla

From the Department of Neurology, University of Miami School of Medicine, Miami, Fla. The present address of Dr. Shalit is Department of Neurosurgery, Hadassah University Hospital, Jerusalem, Israel.

Footnotes
Submitted for publication March 30, 1967; accepted May 6.

Reprint requests to Department of Neurology, University of Miami School of Medicine, Box 875, Biscayne Annex, Miami, Fla 33152 (Dr. Reinmuth).

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