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A. Basil Harris, MD

Arch Neurol. 1967;17(3):282-297.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Steroids )TEROIDS have been widely used to ameliorate the effects of various kinds of cerebral injury. In experimentally induced injury some investigators indicate that steroids are beneficial,^1-7 while others believe them to be without protective value.^8-11 In cats with lengthy exposure of the brain to air, Prados¹ attributed protection against swelling, electroencephalographic alterations, and increased capillary permeability (trypan blue) to the administration of extracts of anterior pituitary or of adrenal cortex. Grenell² repeated the brain exposure experiments in a variety of species and concluded that adrenal cortical extracts prevented structural and functional changes in cerebral cortex.

Blinderman et al³ produced cerebral injury in dogs by the intracarotid injection of vegetable oil. Four of his eight animals treated with methylprednisolone sodium succinate (Solu-Medrol) developed no edema, two did develop it, and two showed equivocal results. The positive effects in the latter four could have been due . . . [Full Text PDF of this Article]

Author Affiliations
St. Louis

From the Division of Neurosurgery, Department of Neurology, and the Beaumont-May Institute of Neurology, Washington University School of Medicine, St. Louis.

Footnotes
Submitted for publication Aug 15, 1966; accepted Dec 23.

Reprint requests to Department of Neurology, Washington University School of Medicine, 660 S Euclid, St. Louis 63110 (Dr. Harris).

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