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An Electron Microscopic Study of the Nervous System

Sarah A. Luse, MD; Collette Chenard, MD; Edward H. Finke, BS

Arch Neurol. 1967;17(2):153-161.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

GENETICALLY determined neurologic variants in inbred mouse colonies are of great interest because they may provide clues to the nature of inherited neurologic diseases in man. The wabbler-lethal (wlwl) mouse, a mutation in the colony at the Roscoe B. Jackson Memorial Laboratory,^1-3 develops neurologic signs early and rarely survives more than a month. Marchi stains reveal myelin involvement in the brain stem and spinal cord with minimal involvement of the cerebrum limited to the internal capsule. Harman^2,4 showed that changes in myelin, already evident at seven days, become increasingly severe during the short life span of affected animals. Similar Marchipositive material was not evident in control material and was only scattered and sparse in littermate heterozygotes.

Harman⁴ considered the wabbler-lethal mouse to have a genetically controlled defect in myelinization. No chemical abnormality was detectable, as is also true in early stages for wallerian degeneration when . . . [Full Text PDF of this Article]

Author Affiliations
St Louis

From the departments of anatomy and pathology, and the Beaumont-May Institute of Neurology, Washington University School of Medicine, St Louis. Dr. Chenard's present address is 1301 Pelletier St, Quebec 6, Canada.

Footnotes
Submitted for publication March 13, 1967; accepted March 30.

Reprint requests to Department of Anatomy, College of Physicians and Surgeons, 630 W 168th St, New York 10032 (Dr. Luse).

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