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"Centrencephalic" Seizure Discharges in Focal Hemispheral Lesions
L. F. Stewart, MD;
F. E. Dreifuss, MB (NZ)
Arch Neurol. 1967;17(1):60-68.
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THE EXPERIMENTAL evidence for the concept of a "centrencephalic" origin for seizures rests on the fact that bilateral epileptic discharge can be set up in homologous areas of the two hemispheres following stimulation of subcortical structures. Jasper and Drooglever-Fortuyn reproduced the bilaterally synchronous wave and spike complex of petit mal by rhythmic electrical stimulation at three per second in the intralaminar nuclei of the thalamus of the cat.1 Later Penfield and Jasper reproduced not only the three per second wave and spike pattern but also clinical evidences of petit mal seizure discharge in cats and monkeys by using implanted electrodes and stimulus between 10 and 20 cycles/sec caused arrest of movement, staring, and unresponsiveness which continued for as long as 30 seconds after the end of stimulation. Higher frequencies and intensities of stimulation, also in the intralaminar nuclei of the thalamus, precipitated generalized convulsive seizures involving both sides
. . . [Full Text PDF of this Article]
Author Affiliations
Charlottesville, Va
From the Division of Neurology, University of Virginia School of Medicine, the Neurological Service, University of Virginia Hospital, and the Commonwealth of Virginia Child Neurology Program, Charlottesville.
Footnotes
Submitted for publication Nov 2, 1966; accepted Jan 27, 1967.
Read before the annual meeting of the Southern Electroencephalographic Society, Tulsa, Okla, Nov 5-6, 1966.
Reprint requests to Division of Neurology, University of Virginia Hospital, Charlottesville, Va 22901 (Dr. Dreifuss).
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