This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Permeability and Electrolyte Metabolism of Brain and Other Tissues

Robert A. Fishman, MD; Neil H. Raskin, MD

Arch Neurol. 1967;17(1):10-21.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CLINICAL experience with the artificial kidney has established that toxic factors responsible for uremic encephalopathy are readily dialyzable, and thereby the neurological manifestation of uremia may be reversed rapidly. Despite greater sophistication in the management of renal insufficiency, the pathophysiology of the encephalopathy is poorly understood, and analyses of brain with traditional neuropathological techniques have failed to yield any specific structural correlations.¹ Therefore, an experimental model of uremia was established in rats in order to characterize physiologically the encephalopathy in terms of several aspects of brain metabolism. Permeability of brain and other tissues was studied, using two nonmetabolized sugars, inulin¹⁴C (molecular weight 5,000) and sucrose¹⁴C (mol wt 342), and sulfate³⁵S, when the latter was corrected for metabolic incorporation into plasma and brain.² Sodium₂₄ and potassium₄₂ transfers were studied because of their pertinence to neural function, and the enzyme, . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Department of Neurology and Neurological Clinical Research Center, College of Physicians and Surgeons, Columbia University and Neurological Institute, Presbyterian Hospital, New York. Dr. Raskin is presently at the National Institutes of Health, Bethesda, Md. Dr. Fishman is now at the University of California Medical Center, San Francisco.

Footnotes
Submitted for publication Feb 20, 1967; accepted March 3.

Read in part before the 1965 meeting of the American Neurological Association, June 14, 1965.

Reprint requests to Department of Neurology, University of California Medical Center, San Francisco 94122 (Dr. Fishman).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati     What's this?