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Excretion of HPPH in the Urine

O. Vendelin Olesen

Arch Neurol. 1967;16(6):642-644.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

TWO DRUGS are used as aids in the treatment of chronic alcoholism in Denmark, namely disulfiram (Antabuse) and calcium carbimide (Dipsan).

An increase in the diphenylhydantoin content of the serum¹ was found in patients given this drug in combination with disulfiram. The administration of the usual therapeutic dose of disulfiram (400 mg daily) for nine days was followed by an increase in diphenylhydantoin content in the serum by 100% to 400%.

The aim of this study was to determine if the rise in serum diphenylhydantoin caused by disulfiram is the result of inhibition of the conversion of diphenylhydantoin to 5-(p-hydroxyphenyl)-5-phenylhydantoin (HPPH) in the liver.

Furthermore, we wished to determine whether the administration of calcium carbimide causes an increase in the diphenylhydantoin content of the serum in patients with epilepsy who require therapy for chronic alcoholism.

Material and Methods

Six male patients who had been treated with diphenylhydantoin for . . . [Full Text PDF of this Article]

Author Affiliations
Dianalund, Denmark

From the Central Laboratory and the Department of Epileptic Diseases, the Filadelfia Colony, Dianalund.

Footnotes
Submitted for publication Nov 14, 1966; accepted Jan 24, 1967.

Reprint requests to the Central Laboratory, Filadelfia Colony, Dianalund, Denmark (Dr. Olesen).

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