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James W. Lance, MD, FRACP; Michael Anthony, MB, MRACP; Alexander Gonski, FRACS

Arch Neurol. 1967;16(5):553-558.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN GENERAL, the infusion of serotonin (5-hydroxytryptamine, 5HT) constricts large arteries and veins but dilates small vessels, although the effect on arterioles depends upon the previous degree of neurogenic vasoconstriction.^1-6 Injection of serotonin into the internal carotid artery of the monkey has been reported as inducing vasoconstriction in the internal carotid circulation,⁷ and direct application of serotonin has been shown to constrict the exposed cerebral blood vessels of the cat and also to produce cortical blanching in some instances.⁸ In contrast to this, Swank and Hissen^" found that flow in the common carotid artery of the dog increased by about 20% in most cases when serotonin was injected into the internal or common carotid arteries. Sicuteri10 reported that the intracarotid injection of serotonin in man increased the amplitude of arterial pulsations recorded during continuous monitoring of cerebrospinal fluid (CSF) pressures, but there is some doubt . . . [Full Text PDF of this Article]

Author Affiliations
Sydney, Australia

From the divisions of neurology and neurosurgery, the Prince Henry Hospital, Sydney, and the School of Medicine, University of New South Wales, Australia. Dr. Anthony is a Sandoz Research Fellow in Neurology.

Footnotes
Submitted for publication Sept 14, 1966; accepted Dec 2.

Reprint requests to Division of Neurology, Prince Henry Hospital, Little Bay, Sydney, NSW, Australia (Dr. Lance).

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