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Cerebrospinal Fluid Pressure Rises Following Intracisternal Infusions of Blood Components in Dogs

J. Donald McQueen, MD; Lawrence F. Jelsma, MD

Arch Neurol. 1967;16(5):501-508.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MANY of the effects of subarachnoid blood deposits are well documented. These include meningeal irritation,^1-3 vasospasm,^4,5 an obstruction to the free flow of cerebrospinal fluid (CSF).^6-10 In previous studies sustained CSF pressure elevations were measured from the surface of the brain after subarachnoid blood injections.^11,12 This work is extended here, and attempts are made to characterize a type of intracranial hypertension and to identify the mechanism. Two groups of experiments are presented: (1) analyses of CSF pressure rises after intracisternal infusions of blood fractions and inert particles and (2) assessments of subarachnoid blockade and other effects.

Method

Animal Preparation.

—The CSF pressures were recorded from the surface of the brain over prolonged periods. For this, adult mongrel dogs (6-15 kg [13.2-33 lb]) were anesthetized with sodium pentobarbital and paralyzed with gallamine triethiodide. The initial doses were 30 and 2 mg/kg; the maintenance dosages were 5 . . . [Full Text PDF of this Article]

Author Affiliations
Baltimore

From the Division of Neurological Surgery, Baltimore City Hospitals and The Johns Hopkins University School of Medicine, Baltimore.

Footnotes
Submitted for publication July 18, 1966; accepted Nov 30.

Reprint requests to Baltimore City Hospitals, 4940 Eastern Ave, Baltimore 21224 (Dr. McQueen).

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