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Robert B. Layzer, MD; Robert E. Lovelace, MB; Lewis P. Rowland, MD

Arch Neurol. 1967;16(5):455-472.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1886 Eulenberg¹ described "paramyotonia congenita," an inherited syndrome in which episodes of myotonia and weakness were induced by exposure to cold. A similar condition was reported independently by Rich.² During the ensuing years additional cases were published, emphasizing the myotonia rather than the episodic weakness which was also part of Eulenberg's original description. A link with periodic paralysis was not considered until 1957, when French and Kilpatrick³ studied a patient with paramyotonia who was subject to attacks of generalized weakness. An oral dose of potassium chloride induced an attack of weakness lasting several days, without a fall in the serum potassium level.

Just prior to the report of French and Kilpatrick, Helweg-Larsen et al⁴ in Denmark and Gamstorp⁵ in Sweden described a hyperkalemic form of periodic paralysis, "adynamia episodica hereditaria." Myotonia was not mentioned in these Scandinavian cases, but paralysis could be induced by . . . [Full Text PDF of this Article]

Author Affiliations
New York

From the Neurological Clinical Research Center, Neurological Institute, Columbia Presbyterian Medical Center, and the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Submitted for publication Nov 16, 1966; accepted Dec 3.

Read in part before the annual meeting of the American Academy of Neurology, Philadelphia, April 1966.

Reprint requests to Department of Neurology, University of California School of Medicine, San Francisco 98105 (Dr. Layzer).

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