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Acute Hemodynamic Changes During Experimental Cerebral Embolism
Yihong Kong, MD;
Gaetano Molinari, MD;
Robert E. Whalen, MD;
Albert Heyman, MD
Arch Neurol. 1967;16(4):433-439.
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THERE is little clinical information available in regard to the hemodynamic changes during the acute phase of cerebral embolism. In experimental animals profound alterations of blood pressure, heart rate, and respiration have been observed following cerebral embolization, but there is no agreement as to direction, magnitude, or mechanisms of these changes.1-4 Furthermore, the hemodynamic alterations observed in many of these studies have not been clearly separated from the effects of respiratory failure or carotid sinus stimulation produced by the experimental procedure.
The present study was designed to determine the degree and the duration of the hemodynamic alterations resulting from experimentally produced cerebral embolism and to study a possible means of preventing these manifestations.
Methods
Ten mongrel dogs weighing 12 to 14 kg (27 to 31 lb) were studied during anesthesia induced by intravenous injection of chloralose and urethane (48 and 480 mg/kg, respectively). Each animal was intubated and
. . . [Full Text PDF of this Article]
Author Affiliations
Durham, NC
From the Center for Cerebrovascular Research and the Cardiovascular Laboratory, Duke University Medical Center, Durham, NC. Dr. Molinari is a trainee supported by the Vocational Rehabilitation Administration.
Footnotes
Submitted for publication Sept 9, 1966; accepted Dec 24.
Read before the annual meeting of the Southern Section of the American Federation for Clinical Research, New Orleans, Jan 29, 1966.
Reprint requests to Duke University Medical Center, Durham, NC 27706 (Dr. Heyman).
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