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Cholinesterase in Adult and Embryonic HypothalamusA Combined Cytochemical Electron Microscopic Study
Philip E. Duffy, MD;
Virginia M. Tennyson, PhD;
Miro Brzin, MD
Arch Neurol. 1967;16(4):385-403.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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THE UNDERSTANDING of the functional significance of the hypothalamus, median eminence, and portal veins to the pituitary may be extended by publications which demonstrate the localization of enzymes in these sites. Although various nerve cells in the hypothalamus have been studied electron microscopically for cholinesterase,1,2 we believe that it is important to specifically select certain nuclear groups for more detailed examination. In the present study the supraoptic, ventromedial, and medial mamillary nuclei of adult rabbits were examined employing a modification of the Koelle-Friedenwald technique.3-5 An embryologic study was also performed to determine at what stage in embryonic life this enzyme is first detected in the hypothalamus and to trace its intraneuronal distribution in later stages of development.
The relationship of certain hypothalamic nuclei and of the median eminence to the pituitary gland has been the subject of many publications. The role of the supraoptic and paraventricular nuclei of
. . . [Full Text PDF of this Article]
Author Affiliations
New York
From the departments of neurology and pathology, Division of Neuropathology, College of Physicians and Surgeons of Columbia University, New York.
Footnotes
Submitted for publication Nov 29, 1966; accepted Dec 9.
Reprint requests to 630 W 168th St, New York 10032 (Dr. Duffy).
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