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Microchemical Architecture of Human Isocortex
Alfred Pope, MD
Arch Neurol. 1967;16(4):351-356.
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DEFINITIVE knowledge of the biochemistry of cerebral cortex is not commensurate with that of its microscopic anatomy or neurophysiological properties. This can partly be attributed to the relatively delayed development of neurochemistry as a whole, and especially of a precise methodology for detailed study of its molecular organization. However, the pioneering development of quantitative histochemistry by K. Linderstrøm-Lang and H. Holter of the Carlsberg Laboratories in Copenhagen and the systematic elaborations and refinements thereof due particularly to two of their distinguished American students, O. H. Lowry and D. Glick, have provided the requisite technology for microneurochemistry. These developments, in turn, have enabled investigations on the molecular and enzymatic architecture of numerous anatomical substituents of mammalian brain including the cerebral cortex of the rat,1-5 rabbit,6 and monkey.7,8
There is, nevertheless, a particular lack of systematic information concerning the biochemistry of the cortex of man in
. . . [Full Text PDF of this Article]
Author Affiliations
Belmont, Mass
From the McLean Hospital Research Laboratory, Belmont, Mass; and the Department of Neurology, Harvard Medical School, Boston.
Footnotes
Submitted for publication Dec 2, 1966; accepted Dec 17.
Read before the annual meeting of the American Neurological Association, Washington, DC, June 15, 1966.
Reprint requests to Research Laboratory, McLean Hospital, Belmont, Mass 02178 (Dr. Pope).
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