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Chronic Occlusion Studies of the Canine Circle of Willis
F. M Knapp, PhD;
W. K. Mitchell, MS
Arch Neurol. 1967;16(3):326-334.
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THE RELATIONSHIP of the circle of Willis to the cerebral blood flow (CBF) has provided considerable speculation.1-4 Circle dynamics have been evaluated by altering or occluding the principal supply vessels.5-8 The majority of these insults to the CBF were limited to periods of only a few minutes to prevent ischemia and possible brain damage. In general, the results from these acute situations were similar, with species differences accounting for most of the variations observed.
Although acute changes in circle dynamics test the temporary effectiveness of this anastomotic arrangement, in more common situations the demands placed upon the circle are the result of chronic, long-term alterations in either the supply vessels or of the circle itself. The present work was undertaken to evaluate pressure relationships existing within the circle of Willis following chronic alteration of the normal supply routes.
The dog was selected because of size, availability, and
. . . [Full Text PDF of this Article]
Author Affiliations
Pittsburgh; Galesburg, Ill
From the Department of Biological Sciences. Duquesne University, Pittsburgh (Dr. Knapp); and Thudichum Psychiatric Research Laboratory, Galesburg State Research Hospital, Galesburg, Ill (Mr. Mitchell). Mr. Mitchell's present address is Department of Biology, University of Wyoming, Laramie.
Footnotes
Submitted for publication Nov 3, 1966; accepted Nov 18.
Reprint requests to Department of Biological Sciences, Duquesne University, Pittsburgh, Pa 15219 (Dr. Knapp).
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