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Edward Lewin, MD; Aubry McCrimmon, BS

Arch Neurol. 1967;16(3):321-325.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE PRODUCTION of abnormally discharging cortical foci in experimental animals provides a model having some resemblance to human focal epilepsy. Local cortical freezing is one of several procedures which have been effective in producing epileptogenic lesions. Nims et al employed an ethyl chloride spray to produce a freezing cortical lesion,¹ and more recently Morrell et al have described in detail results with the same method.² Although the rat has been said to be relatively resistant to cortical freezing,³ Morrell's technique has proved effective in inducing abnormally discharging lesions in this animal, and experience with the rat will be described.

Such lesions should be useful for investigating chemical alterations associated with the resulting electroencephalographic abnormality. The ATPase requiring Na⁺ and K⁺ as well as Mg⁺⁺ for full activation (Na-K-ATPase) was selected for study because of the suggested association of this enzyme with transport of Na⁺ and K . . . [Full Text PDF of this Article]

Author Affiliations
Denver

From the Division of Neurology, University of Colorado Medical Center, and the Veterans Administration Hospital, Denver.

Footnotes
Submitted for publication July 30, 1966; accepted Nov 18.

Reprint requests to Veterans Administration Hospital, Denver 80220 (Dr. Lewin).

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