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Normal Events and Effects of Intra-Uterine Neurosurgical Lesions

William DeMyer, MD

Arch Neurol. 1967;16(2):203-211.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE CORTICOSPINAL tracts are present in all Mammalia and have provoked more studies than any other tract. Nevertheless, the vast literature contained little ontogenic information until Humphrey's account of human corticospinal tract development.¹ Perhaps one reason for the lack of ontogenic data is that investigators have despaired of operating on the mammalian fetus to study the dynamics of tract formation. Efforts of the few previous workers in fetal surgery^2-5 have now been extended by personal experiments showing that the rat fetus can survive a variety of neurosurgical operations. The fetus can then be delivered and nurtured into adulthood by a few simple techniques.⁶ Thus far, rats have survived postnatally after intra-uterine spinal cord transection, destruction of one hemispheric wall, destruction of the dorsal column nuclei, destruction of the rhombic lip, or optic enucleation. The rat fetuses were operated on during day 15.5 or 16.5 of gestation, . . . [Full Text PDF of this Article]

Author Affiliations
Indianapolis

From the Indiana University Medical Center, Indianapolis.

Footnotes
Submitted for publication Sept 30. 1966; accepted Oct 11.

Reprint requests to Indiana University Medical Center, 1100 W Michigan St, Indianapolis 46207.

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