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A Recessively Inherited Form of Presenile Dementia With Motor Disturbances

HAROLD E. CROSS, MD; VICTOR A. McKUSICK, MD

Arch Neurol. 1967;16(1):1-13.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

MANY aspects of the nosology of hereditary degenerative disorders of the nervous system remain obscure, and as yet no adequate system of classification is available.¹ In considerable part this is due to insufficient clinical, biochemical, pathological, and genetic information. The rarity of many neurological disorders makes a comprehensive study difficult, and few observers are able to personally examine sufficient material to make valid comparisons.^1,2

Several types of genetic information derived from inbred populations may be especially useful in the investigation of heredodegenerative neurological disorders. The Old Order Amish of Holmes County, Ohio, and similar settlements in Indiana and Pennsylvania, each comprise a genetic isolate with many characteristics favorable for genetic studies.³ A preliminary communication⁴ reported several previously undescribed hereditary neurological syndromes found among the Ohio Amish. This report presents detailed clinical and genetic findings of one of these disorders tentatively designated the Mast syndrome from . . . [Full Text PDF of this Article]

Author Affiliations
BALTIMORE

From the Division of Medical Genetics, Department of Medicine, the Johns Hopkins University School of Medicine, and the Johns Hopkins Hospital, Baltimore.

Footnotes
Submitted for publication July 28, 1966; accepted Sept 20.

Reprint requests to Moore Clinic, Johns Hopkins Hospital, Baltimore 21205 (Dr. Cross).

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