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Electron Microscopic Evidence

J. FRANCIS HARTMANN, PhD

Arch Neurol. 1966;15(6):633-642.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

FOR MORE than a decade, an unexplained disparity has existed between the values for extracellular space in the cerebral cortex obtained by different methods. Electron microscopy of thin sections has revealed, with rare exceptions, a space between cells or cell processes measuring only 150 to 200 Angstrom wide.^1-5 More recently, localized obliterations of even this small gap by the formation of so-called tight junctions^6-8 has been described. Calculations based on measurement of the cortical extracellular space in electron micrographs⁹ yield a maximum value of 5% for this compartment as a fraction of total cortical volume. Not only has a consistent average value of 200 A for the width of the intercellular gap been measured in electron micrographs of normal cerebral cortex fixed and embedded in various ways, but brain slices incubated in vitro^10,11show astrocytic swelling without change in the dimensions of the extracellular space. A . . . [Full Text PDF of this Article]

Author Affiliations
CHICAGO

From the Department of Neurology, Presbyterian-St. Luke's Hospital, Chicago.

Footnotes
Submitted for publication July 22, 1966; accepted Aug 18.

Read before the 91st Annual Meeting of the American Neurological Association, Washington, DC, June 14, 1966.

Reprint requests to Department of Neurology, Presbyterian-St. Luke's Hospital, 1753 W Congress Parkway, Chicago 60612 (Dr. Hartmann).

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