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A. N. D'AGOSTINO, MD; K. R. BRIZZEE, PhD, MD

Arch Neurol. 1966;15(6):615-628.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN FETUSES exposed to 130 roentgens on the 13th day of gestation cellular necrosis in the cerebral vesicles is a consistent occurrence.^1-3 Subsequently, reparative processes are evident,¹ rosettes are formed, and malformations ensue.^2-5 In this study the central nervous system (CNS) of fetuses was examined at intervals from ten minutes to six days following irradiation in utero, and the morphologic features of irradiation-induced cellular necrosis and repair are reported.

Materials and Methods

Pregnant female rats of the Sprague-Dawley strain were exposed to 130 R of whole body x-irradiation on the 13th day of gestation. The radiation was administered from the dorsal aspect with a 300-unit maxitron operated at 250 kilovolt (peak) (KVP) and 15 ma at the rate of 60 R/min. The calibration for appropriate dosage was made with an R meter, placed in a wax phantom at a depth corresponding to the depth of fetuses below . . . [Full Text PDF of this Article]

Author Affiliations
SALT LAKE CITY

From the departments of neurology, pathology, and anatomy, University of Utah College of Medicine, Salt Lake City.

Footnotes
Submitted for publication July 22, 1966; accepted Aug 25.

Reprint requests to Department of Neurology, University of Utah Medical Center, Salt Lake City 84112 (Dr. D'Agostino).

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