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N. A. LASSEN, MD; S. CHRISTENSEN, MD; K. HOEDT-RASMUSSEN, MD; B. M. STEWART, MD

Arch Neurol. 1966;15(6):595-602.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

A CLOSE correlation between mental function and cerebral oxygen uptake (CMRO₂) has been established by numerous clinical studies with the Kety-Schmidt inert gas saturation technique. A subnormal CMRO₂ is invariably found in the acute depression of brain function that clinically manifests itself as semicoma or coma, eg, as caused by narcotic drugs.^1-4 Of special pertinence to the present study is the marked reduction of CMRO₂ that accompanies the chronic depression of brain function characterizing senile and presenile dementia as well as all other forms of organic dementia in adults.^5-7

Severe chronic dementia in infancy and early childhood (the idiocies) has so far been studied to a very limited extent with regard to CMRO₂. Garfunkel et al found reduced CMRO₂ in children with various types of severe neurological disorders with dementia.⁸ Similar results were obtained in four patients with microcephaly and idiocy studied . . . [Full Text PDF of this Article]

Author Affiliations
COPENHAGEN

From the Department of Clinical Physiology, Bispebjerg Hospital, Copenhagen. Dr. Stewart is on leave of absence from the Department of Neurology, St. Michaels Hospital, Toronto.

Footnotes
Submitted for publication Feb 28, 1966; accepted Aug 25.

Reprint requests to Department of Clinical Physiology, Bispebjerg Hospital, Bispebjerg Bakke 23, Copenhagen (Dr. Lassen).

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