This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (23)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

ALLAN L. SHERWIN, MD, PhD

Arch Neurol. 1966;15(3):289-293.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

STUDIES of the experimental allergic neuropathy, which can be produced in animals by immunization with peripheral nervous tissue, have been largely concerned with the phenomena observed in the acute stage. As originally demonstrated by Waksman and Adams¹ in the rabbit, the pathological changes are confined to the peripheral nervous system, sparing structures of the central nervous system (CNS) except for the occasional accumulation of inflammatory cells in the meninges. The clinical features of a gradually ascending symmetrical polyneuropathy, accompanied by an increase in the cerebrospinal fluid protein, resemble certain human polyneuropathies such as the Guillain-Barré syndrome.

Usually single severe attacks characterize the experimental rabbit disease with occasional repeat episodes being observed. Heitmann and Mannweiler² noted a shorter incubation period in the rabbit when the inoculation was repeated several months after primary immunization. In the monkey Heitmann et al³ noted a predilection for the neuropathy to affect cranial . . . [Full Text PDF of this Article]

Author Affiliations
MONTREAL

From the Department of Neurology and Neurosurgery, McGill University, and the Montreal Neurological Institute, Montreal.

Footnotes
Submitted for publication June 7, 1966; accepted June 20.

Reprint requests to Montreal Neurological Institute, 3801 University St, Montreal 2.

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?