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PAUL SLOTWINER, MD; S. K. SONG, MD; PAUL J. ANDERSON, MD

Arch Neurol. 1966;15(2):172-176.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

VINCRISTINE SULFATE is an alkaloid with oncolytic activity obtained from the periwinkle plant, Vinca rosea Linn.^1,2 Its mode of action has not been clarified, but it has been shown to arrest mitotic division in metaphase.^3,4 The drug has been used for the treatment of a variety of neoplasms, particularly acute leukemia in children.^5-10 From reports in the literature^11-13 and personal observations, it has been noted that patients receiving vincristine often develop flaccid distal weakness, distal paresthesias, and depression or extinction of deep tendon reflexes, all of which are readily reversible on cessation of treatment, suggesting a drug-induced peripheral neuropathy. This study was undertaken to determine the histopathologic and histochemical effects of vincristine on the nerve and muscle.

Material and Methods

A group of 40 male Sprague-Dawley rats, weighing 165 to 280 gm (6-10 oz), were injected intraperitoneally with vincristine sulfate in doses ranging from 0.2 . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Division of Neuropathology, Mount Sinai Hospital, and the Division of Neuropathology, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Submitted for publication March 3, 1966; accepted March 21.

Reprint requests to Division of Neuropathology, Mount Sinai Hospital, 1 E 100th St, New York 10029 (Dr. Slotwiner).

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