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III. Studies Based on Homologous Skin Grafts to the Brain and Subcutaneous Tissues *

LABE C. SCHEINBERG, MD; D. G. KOTSILIMBAS, MD; R. KARPF, AB; N. MAYER, AB

Arch Neurol. 1966;15(1):62-67.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE CONCEPT of the brain as "an immunologically privileged site" has come about as a result of the investigations of Medawar¹ and Greene.^2-4 Medawar¹ showed that the brain does not respond with the typical "primary or secondary set reaction" histologically when homologous skin is implanted in the cerebrum. Greene^2-4 demonstrated that the brain will accept tumor homotransplants or heterotransplants which were rejected when transplanted to other sites under ordinary circumstances. These phenomena and the failure to demonstrate lymphatic channels in the brain have led to the concept that the brain is "an immunologically privileged site."

Scheinberg et al^5,6 have subsequently demonstrated that this "immunologic privilege of the brain" appears to be far from perfect. In their initial studies⁵ they demonstrated a variable acceptance of tumor homotransplants by the brain with rejection of all tumor homotransplants by the subcutaneous tissues. Tumor isotransplants were almost . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Saul R. Korey Department of Neurology and the Department of Neurological Surgery, Albert Einstein College of Medicine of Yeshiva University, New York.

Footnotes
Submitted for publication March 25, 1966; accepted April 11.

Reprint requests to Department of Neurology, Albert Einstein College of Medicine, New York 10461 (Dr. Scheinberg).

Part I, "Studies Based on Intracerebral Tumor Homotransplantation and Isotransplantation to Sensitized Hosts" may be found in the September 1964 issue of the Archives, pp 248-264; part II, "Studies in Induced Host Resistance to Transplantable Mouse Glioma Following Irradiation of Prior Implants" in September 1965, pp 283-286.

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