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III. Effects of Lesions of the Periaqueductal Gray Matter and Rostral Hypothalamus*

F. MILES SKULTETY, MD

Arch Neurol. 1966;14(6):670-680.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

OBESITY or hyperphagia or both have been reported after central nervous system lesions in regions other than the hypothalamus including the frontal lobes,^1-3 temporal lobes and amygdala,^4,5 thalamus,^6-8 globus pallidus,⁹ and midbrain.^7,10-14

Decerebrate animals are capable of reflex chewing and swallowing. Both Miller and Sherrington¹⁵ and Bazett and Penfield¹⁶ have demonstrated that these simple feeding-responses are possible after removal of much of the mesencephalon and more rostral portions of the brain. Ruch et al⁷ reported an apparent hyperphagia in monkeys with lesions involving the rostral mesencephalon and ventral thalamus. Sprague et al¹⁴ demonstrated an increased intake in cats with bilateral lesions of the lateral midbrain, and Randall¹¹ subsequently reported that cats with bilateral ventrolateral lesions of the caudal midbrain became extremely obese and lethargic.

Adametz and O'Leary¹⁰ first mentioned an "excessive appetite" in cats following lesions of . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Division of Neurosurgery, University of Iowa College of Medicine, Iowa City.

Footnotes
Submitted for publication Dec 15, 1965; accepted Jan 11, 1966.

Read in part before the meeting of the American Association of Anatomists in Miami, April 20-23, 1965.

Reprint requests to Division of Neurosurgery, University of Iowa College of Medicine, Iowa City 52241.

Part I, "Preoperative Observations" may be found in the April 1966 issue of the Archives, pp 428-437; Part II, "Effects of Lesions in Medial Hypothalamic Region" may be found in the May 1966 issue of the Archives, pp 541-552.

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