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III. Edema in Shark Brain*

LOUIS BAKAY, MD; JOSEPH C. LEE, MD, PhD

Arch Neurol. 1966;14(6):644-660.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN THE course of our electron microscopic investigation of various types of experimental edemas of the brain,^1,2 the complexity of the central nervous system (CNS) of mammals and the variety of its cells became a limiting factor in evaluating the significance of some of the observations. It was felt that a primitive brain, yet, a brain that contained all the essential structural elements of the nervous system of mammals, namely, nerve cells, glia cells, myelin sheaths, and an intracerebral network of blood vessels, would lend itself very well to studying edema formation in a relatively simple system. The criteria imposed by us excluded the use of invertebrates or such primitive vertebrates as cyclostomata because of the dissimilarity of their blood supply to the CNS and the lack of myelin sheaths.^3,4 This latter structure was essential to the study of cerebral edema because most forms of brain swelling are . . . [Full Text PDF of this Article]

Author Affiliations
BUFFALO, NY

From the Neurosurgical Research Laboratory, The Buffalo General Hospital, the Division of Neurosurgery of the State University of New York at Buffalo School of Medicine, Buffalo, NY, and the Lerner Marine Laboratory of the American Museum of Natural History, Bimini, Bahamas.

Footnotes
Submitted for publication Feb 8, 1966; accepted Feb 26.

Reprint requests to the Buffalo General Hospital, 100 High Street, Buffalo, NY 14203 (Dr. Bakay).

Part I, "Triethyltin Edema," may be found in the July 1965 issue of the ARCHIVES, pp 48-57; part II, "Cold-Induced Edema," in the January 1966 issue of the Archives, pp 36-49.

*The shark physiological saline solution contained: NaCl 280.0 mM, KC1 8.0 mM, NaHCO3 4.5 mM, NaH2PO4 0.15 mM, urea 360.0 mM, CaCl2 10.0 mM, MgCl2 5.0 mM.

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