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II. Effects of Lesions in Medial Hypothalamic Region*

F. MILES SKULTETY, MD

Arch Neurol. 1966;14(5):541-552.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE DEVELOPMENT of obesity or hyperphagia or both following lesions in the region of the hypothalamus has been reported in rats,^1-5 mice,^6,7 dogs,^8-10 cast,^1,11-13 and monkeys.^11,14-17 Most lesions were produced by electrolysis in the general region of the hypothalamic ventromedial nuclei bilaterally. However, Bailey and Bremer⁸ reported that their lesions were in the posterior hypothalamus in dogs; and Heinbecker et al⁹ reported that their lesions, also in dogs, were in the paraventricular nuclei. Mayer⁶ produced hyperphagia and obesity in mice by feeding aurothioglucose.

The assumption that bilateral destruction of the ventromedial hypothalamic nuclei constitute the essential lesion is not unequivocally established in the literature. Brobeck et al² reported hyperphagia and obesity in albino rats after lesions in the ventromedial region of the hypothalamus in which the ventromedial nuclei were not destroyed bilaterally. Kennedy⁵ produced hyperphagic rats with hypothalamic lesions . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Division of Neurosurgery, University of Iowa College of Medicine, Iowa City.

Footnotes
Submitted for publication Dec 15, 1965; accepted Jan 11, 1966.

Read in part before the meeting of the American Association of Anatomists in Miami, April 20-23, 1965.

Reprint requests to Division of Neurosurgery, University of Iowa College of Medicine, Iowa City 52241.

Part I, "Preoperative Observations," may be found in the April issue of the ARCHIVES, pp 429-438.

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