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Some Therapeutic and Diagnostic Considerations

DEWEY K. ZIEGLER, MD

Arch Neurol. 1966;14(5):476-488.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DESPITE several years of speculation and considerable clinical trial, the efficacy of corticotropin or adrenal cortical steroid compounds in the treatment of demyelinating diseases remains doubtful.^1-4 Of these diseases acute disseminated encephalomyelitis would be expected to respond best to the drugs because of its resemblance clinically to the experimental disease, "allergic" encephalitis, which is definitely inhibited by the compounds.^1,5-7 Clinical data seem to have borne out this predicition,^8-14 but reports are sparse and controlled studies are absent. The treatment, therefore, while generally used, is not firmly established. The problem is particularly difficult since the clinical diagnosis can never be proven in life, and the disease is difficult to differentiate from other encephalitides. The following five cases are reported to add confirmation of clinical effectiveness of corticotropin and adrenal steroids in probable cases of acute disseminated encephalomyelitis and, in particular, to call attention to the inadvertent natural . . . [Full Text PDF of this Article]

Author Affiliations
KANSAS CITY, KAN

From the Department of Medicine, Section of Neurology, Kansas University Medical Center, Kansas City, Kan.

Footnotes
Submitted for publication Nov 18, 1965; accepted Jan 20, 1966.

Reprint requests to Kansas University Medical Center, 39th and Rainbow Blvd, Kansas City, Kan 66103.

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