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IV. Optic Neuropathy and Multiple Sclerosis

URI LEIBOWITZ, MD; MILTON ALTER, MD; LIPMAN HALPERN, MD

Arch Neurol. 1966;14(5):459-466.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE is a widely held impression that visual deficit due to retrobulbar or optic neuritis is commonly the first sign of multiple sclerosis.^1-4 Indeed, an authority⁵ states that "there is only one common cause of unilateral retrobulbar neuritis, namely, multiple sclerosis." However, the question of whether cases of unexplained and isolated optic neuropathy should be diagnosed as multiple sclerosis is still disputed in the literature. A number of investigators^6-11 who followed patients for 10 to 15 years found that about a third of those with unexplained optic neuropathy later developed signs of disseminated neurological deficit. Others^12,13 consider that optic neuropathy is rarely followed by neurological deficit compatible with multiple sclerosis.

Besides the question of how frequently patients with optic neuropathy develop disseminated neurological deficit, there is a question of whether those who suffer optic nerve damage at onset of multiple sclerosis differ in clinical course . . . [Full Text PDF of this Article]

Author Affiliations
JERUSALEM, ISRAEL

From the Department of Neurology, Hadassah University Hospital, Jerusalem, Israel (Dr. Leibowitz and Dr. Halpern) and from the Division of Neurology, University of Minnesota, Minneapolis (Dr. Alter).

Footnotes
Submitted for publication Nov 3, 1965; accepted Jan 11, 1966.

Reprint requests to Hadassah University Hospital, P.O.B. 499, Jerusalem, Israel (Dr. Leibowitz).

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