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LEON D. PROCKOP, MD

Arch Neurol. 1966;14(3):326-330.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PROCAINE amide hydrochloride has been used widely to treat cardiac arrhythmia during the past 15 years,¹ and it is also useful in the treatment of myotonia.^2,3 There have been reports of minor side effects (fever, rash, arthralgia, chills, headache, myalgia, lymphadenopathy, leukopenia, and eosinophilia^4-9) which subside after medication is withdrawn, and there has been one case of fatal agranulocytosis.¹⁰

During the past few years there have been several observations of a syndrome resembling systemic lupus erythematosus (SLE) in patients receiving procaine amide (Table 1). The present report describes this syndrome in a patient with myotonic muscular dystrophy. By way of contrast, we also describe a patient with chronic SLE who received the drug with no deleterious effect in the treatment of an unusual intercurrent myotonic disorder.

Report of Cases

CASE 1.—This case involves a transient syndrome resembling SLE in a patient treated with procaine amide . . . [Full Text PDF of this Article]

Author Affiliations
NEW YORK

From the Neurological Clinical Research Center, Neurological Institute, Columbia-Presbyterian Medical Center and the Department of Neurology, College of Physicians and Surgeons, Columbia University, New York.

Footnotes
Submitted for publication Nov 19, 1965; accepted Dec 6.

Reprint requests to Neurological Institute, 710 W 168th St, New York 10032.

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