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DAVID M. DAWSON, MD

Arch Neurol. 1966;14(3):321-325.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Clinical and experimental observations have established that damaged or degenerating muscles will release its contents, particularly enzymes, into the general circulation, and that this process can be measured by an increase in the level of certain enzymes in the serum. Assay of serum enzymes in the assessment of muscle disease has been employed most widely in the study of muscular dystrophy both to establish the diagnosis early^1,2 and to discover maternal carriers of the sex-linked form.^3,4 However, it is clear that at least some muscle enzymes are released into serum by other myopathies, particularly acute myositis,^5,6 and even by neurogenic atrophy.^5,6

That the source of the serum enzymes is indeed the muscle has been established by a number of findings. Dreyfus et al⁷ showed that the venous aldolase level was sometimes slightly higher than the arterial aldolase in cases of muscular dystrophy. The isoenzymes of . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Neurological Unit, Boston City Hospital, and the Department of Neurology, Harvard Medical School.

Footnotes
Submitted for publication Oct 15, 1965; accepted Nov 13.

Reprint requests to Neurological Unit, Boston City Hospital, Boston.

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