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Corticostriate Encephalitis and Paraballism in the MonkeyEvidence Concerning Distinctive Functions of the Globus Pallidus
MALCOLM B. CARPENTER, MD;
NORMAN L. STROMINGER, PhD
Arch Neurol. 1966;14(3):241-253.
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THIS REPORT presents physiological and pathological observations made upon a rhesus monkey with acute encephalitis of unknown etiology associated with large amplitude, forceful choreoid activity. The type of choreoid activity exhibited by this animal was indistinguishable from that produced in the monkey by discrete lesions in the subthalamic nucleus,1-4 except that the dyskinesia was bilateral, involved all extremities, and developed spontaneously. Observations made in this study, interpreted with respect to recent anatomical findings, offer an explanation concerning the neural mechanism of choreoid dyskinesia resulting from lesions involving the lateral segment of the globus pallidus. Evidence also is presented indicating that the medial and lateral segments of the globus pallidus each have certain unique and different functions.
In the clinical literature severe bilateral choreoid activity of large amplitude has been designated under the term "paraballism."5,6 It is of interest that, in the published clinicopathological reports of paraballism,5,7-10
. . . [Full Text PDF of this Article]
Author Affiliations
NEW YORK
From the Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York.
Footnotes
Submitted for publication Oct 26, 1965; accepted Nov 12.
Reprint requests to College of Physicians & Surgeons, 630 W 168 St, New York 10032 (Dr. Carpenter).
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