This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

Hypophysectomy in Man

JOEL F. HABENER, MD; ALFRED M. DASHE, MD

Arch Neurol. 1966;14(2):177-183.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

PITUITARY ABLATION by stereotactic transnasal Yttrium Y 90 implantation has been carried out at this institution in a number of patients with advanced metastatic mammary carcinoma.¹ The occurrence of subsequent water intoxication and the ultimate degree of diabetes insipidus varied from case to case, indicating that the interruption of the hypothalamico-hypophyseal system was frequently incomplete.² The question is: Are these disturbances determined by the degree of pituitary damage or by the degree of retrograde loss of hypohyponeurons, or both?

In the present study an attempt was made to correlate diabetes insipidus with hypothalamic damage by assessing the degree of nuclear and neuronal atrophy occurring in the supraoptic (SON) and paraventricular (PVN) nuclei of five patients who died from 5 to 20 months following Yttrium Y 90 hypophysectomy and in whom both anterior and posterior pituitary function had been studied preoperatively and postoperatively. Estimates of degree of . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

From the departments of pathology and medicine, University of California, Center for the Health Sciences, Los Angeles.

Footnotes
Submitted for publication July 27, 1965; accepted Oct 18.

Reprint requests to UCLA Center for the Health Sciences, Los Angeles, 90024 (Dr. Dashe).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?