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III. Correlative Analysis of Conditioned Approach Behavior and Brain Levels of Serotonin and Catecholamines in Monkeys

JUHN A. WADA, MD; EDITH G. McGEER, PhD

Arch Neurol. 1966;14(2):129-142.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN AN EARLIER work on the correlation of behavior and central aromatic amine levels, we studied conditioned avoidance behavior in cats.^1,2 The results indicated that (1) the maintenance of an intricate equilibrium among the various amines seems of importance for the learned performance of avoidance behavior, and (2) an enhancement of catecholamines and decrement of serotonin seem to be correlated with an improvement in avoidance performance, while an enhancement of serotonin and a decrement of catecholamines seem correlated with a deterioration of avoidance performance.

Because of the limited significance of the single test behavior used and possible species differences, we have selected macaque monkeys and conditioned approach-response for a second study reported in this paper.

Materials

Twenty macaque monkeys, 11 males and 9 females, weighing 3.3-4.5 kg (7-10n lb), were used. Five of these were used for a behavioral study, but one female died in the early stages . . . [Full Text PDF of this Article]

Author Affiliations
VANCOUVER, CANADA

From the Kinsmen Laboratory of Neurological Research, Faculty of Medicine, University of British Columbia, Vancouver, Canada.

Footnotes
Submitted for publication May 10, 1965; accepted Aug 6.

Reprints to Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada (Dr. Wada).

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