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II. Cold-Induced Edema*

JOSEPH C. LEE, MD, PhD; LOUIS BAKAY, MD

Arch Neurol. 1966;14(1):36-49.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

CEREBRAL EDEMA produced by localized cortical freezing has become an experimental modus operandi since the introduction of an easily reproducible technique by Hass and Taylor in 1948.¹ This technique was refined subsequently.^2-4 A review of the literature shows that, regardless of freezing agents and sites of application, the results obtained from different animal species are essentially the same, namely, a focal hemorrhagic lesion in the cerebral cortex accompanied by wide-spread edema in the white matter of the damaged hemisphere. The details of pathological changes studied by histological, chemical, and tracer methods were previously reported by one of us.⁵

In contrast to the extensive light microscopic investigation of cold-induced edema, the ultrastructural changes have been studied only by Torack et al.⁶ These authors limited their electron microscopic examination to the cerebral cortex adjacent to the lesion. For this reason their observations cannot be extended to . . . [Full Text PDF of this Article]

Author Affiliations
BUFFALO

From the Neurosurgical Research Laboratory, Buffalo General Hospital, Buffalo.

Footnotes
Submitted for publication Aug 16, 1965; accepted Oct 1.

Reprint requests to Buffalo General Hospital, 100 High St, Buffalo, NY 14203 (Dr. Bakay).

Part I, "Triethyltin Edema" may be found in the July 1965 issue of the Archives, pp 48-57.

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