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Myotubular MyopathyPersistence of Fetal Muscle in an Adolescent Boy
ALFRED J. SPIRO, MD;
G. MILTON SHY, MD;
NICHOLAS K. GONATAS, MD
Arch Neurol. 1966;14(1):1-14.
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| Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings. |
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FOR SEVERAL WEEKS prior to the formation of mature muscle cells, the process of which is virtually completed by the fifth fetal month in humans,1 the cell exists as a myotube. Similar muscle cells were seen in the biopsy of an adolescent boy with a muscle-wasting disorder.
Since this unusual pathological occurrence appears to be unique, it is the purpose of this report to present the clinical, pathological, cytochemical, and electron microscopic studies of this disease. An attempt will also be made to correlate these findings with previously reported studies in myogenesis.
Methods
Biopsy specimens of gastrocnemius muscle were removed on two separate occasions (September 1962 and January 1965) after infiltration of the overlying skin with a local anesthetic. The initial specimen was removed with sutures and fixed in Zenker's solution; the second specimen was removed with a C-shaped clamp designed for that purpose, and fixed in Bouin's solution.
. . . [Full Text PDF of this Article]
Author Affiliations
PHILADELPHIA
From the departments of neurology and pediatrics, University of Pennsylvania, Philadelphia.
Footnotes
Submitted for publication July 16, 1965; accepted Sept 13.
Read in part at the Scientific Conference of the observance of the Bicentennial of Medical Education in the United States of America, University of Pennsylvania, Philadelphia, May 21, 1965.
Reprint requests to 1740 Bainbridge St, Philadelphia, Pa 19146 (Dr. Spiro).
Duxford, Cambridge, England.
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