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ROBERT J. JOYNT, MD; ADEL AFIFI, MD; JOHN HARBISON, MD

Arch Neurol. 1965;13(6):633-638.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THE SYNDROME of inappropriate secretion of the antidiuretic hormone (ADH) was originally described by Schwartz and his co-workers¹ in two patients with bronchiogenic carcinoma. The most outstanding clinical findings were the signs and symptoms of water intoxication, and the outstanding laboratory finding was hyponatremia. Fuisz,² in an extensive review of hyponatremia, has outlined the following criteria for diagnosis of inappropriate ADH secretion: (1) hyponatremia, (2) renal sodium loss and hypertonic urine, (3) symptoms of water intoxication, (4) resistance to correction by hypertonic saline infusions, and (5) reversibility following water restriction.

The syndrome has been described in a variety of disease states, many of them involving the central and peripheral nervous system. It has been seen with cerebral injury,³ encephalitis,⁴ poliomyelitis,⁴ meningitis,⁵ polyneuritis,⁶ diffuse cerebral damage in infancy,⁷ supratentorial⁸ and infratentorial⁹ brain tumors, following irradiation of an intrasellar tumor,¹⁰ . . . [Full Text PDF of this Article]

Author Affiliations
IOWA CITY

From the Neurosensory Center and Department of Neurology, College of Medicine, University of Iowa, Iowa City.

Footnotes
Submitted for publication July 23, 1965; accepted Aug 2.

Read by title at the American Neurological Association Meeting, Atlantic City, NJ, June 14-16, 1965.

Reprint requests to University Hospital, Iowa City, Iowa 52241 (Dr. Joynt).

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