This Article  • References  • Full text PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (8)  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Social Bookmarking   What's this?

DARRYL DeVIVO, MD; EDMUND KLINE, MD; PHILLIP R. DODGE, MD

Arch Neurol. 1965;13(6):615-620.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

Introduction

SEVERAL YEARS ago an hydrocephalic infant died of sepsis, extensive intravascular thrombosis, and afibrinogenemia following a ventriculoatriostomy. Although it was recognized at that time that this complication was explicable on the basis of infection and shock, the question was posed, did the introduction of cerebrospinal fluid (CSF) into the circulation affect coagulation in vivo and might this become an important factor in limiting the effectiveness of shunt surgery? Since then complications of ventriculoatriostomy have been encountered frequently and local clotting with or without infection has often plagued success. But extensive intravascular clotting has never been encountered subsequently by us in over 65 cases, and has not to our knowledge been reported by others. Nevertheless, this isolated experience prompted us to study the influence of CSF on various in vitro blood clotting systems. The present report is based on these studies.

Methods and Materials

Plasma (oxalated) and serum samples were . . . [Full Text PDF of this Article]

Author Affiliations
BOSTON

From the Department of Neurology, Harvard Medical School and the Neurology and Childrens' Services, and the Joseph P. Kennedy, Jr. Memorial Laboratories, Massachusetts General Hospital.

Footnotes
Submitted for publication Dec 31, 1964; accepted Sept 15, 1965.

Reprint requests to Massachusetts General Hospital, Boston, Mass 02114 (Dr. Dodge).

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?