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WILLIAM H. OLDENDORF, MD; MASAMI KITANO, MD

Arch Neurol. 1965;13(5):533-540.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

THERE IS GENERAL recognition of increased tissue copper content reflecting an increased tissue uptake of dietary copper in Wilson's disease. Presented here are results of clinical radioisotope studies intended to elaborate certain mechanisms related to the increased tissue copper uptake in Wilson's disease.

In an earlier report a single-injection, clinical technique was described which allows the measurement of the rate of uptake by brain of -emitters circulating in the blood.¹ Included was a brief description of the demonstration of increased⁶⁴Cu uptake by brain in Wilson's disease (hepatolenticular degeneration). The present report will describe, in detail, results in two cases of Wilson's disease studied in this way. As controls, five normals, five patients with Laennec's cirrhosis and one case of Huntington's chorea have been similarly studied.

In addition to this single-injection technique a second closely related method of continuous infusion was applied in several subjects. In both techniques . . . [Full Text PDF of this Article]

Author Affiliations
LOS ANGELES

From the Neurology Section, Medical Service, Wadsworth Hospital, Veterans Administration Center and the Division of Neurology, Department of Medicine, UCLA Center for the Health Sciences, Los Angeles. Associate professor of Medicine (Neurology), in Residence, Department of Medicine, UCLA Center for the Health Sciences (Dr. Oldendorf); Assistant Research Neurologist, Department of Medicine (Neurology) (Dr. Kitano).

Footnotes
Submitted for publication May 20, 1965; accepted July 7.

Reprint requests to Veterans Administration Center, Los Angeles, Calif 90073 (Dr. Oldendorf).

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