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DAVID M. ROBERTSON, MD; J. DICK MacLEAN, BA

Arch Neurol. 1965;13(3):287-296.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

IN 1932 Russell¹ observed that round or oval eosinophilic intranuclear inclusions occurred in 63 of 192 gliomas, with the highest incidence (61%) being in glioblastoma multiforme. The inclusions were 3µ to 17.5µ in diameter, homogeneous or finely granular, and sharply outlined by a thin basophilic "capsule." Nuclei with inclusions were generally enlarged and frequently hyperchromatic. It was thought that the inclusions resembled those occurring in virus-infected cells and were compatible with being the result of viral activity. Although the author suggested that the inclusions could be distinguished from nuclear folds containing cytoplasm, it is noteworthy that the staining reactions of the former were similar to those expected of cytoplasm.

Subsequently Wolf and Orton² reported the presence of morphologically similar inclusions in 16 of 33 glioblastomas and in other forms of intracranial tumors. Again the resemblance to viral inclusions was commented upon, and it was suggested . . . [Full Text PDF of this Article]

Author Affiliations
KINGSTON, ONTARIO, CANADA

From the Department of Pathology, Queen's University and Kingston General Hospital, Kingston, Ontario, Canada. Assistant Professor of Pathology (Dr. Robertson).

Footnotes
Submitted for publication April 23, 1965; accepted May 20.

Reprint requests to Department of Pathology, Queen's University, Kingston, Ontario. (Dr. Robertson).

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