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JAMES L. O'LEARY, MD; A. BASIL HARRIS, MD; RICHARD R. FOX; JEANNE MARIE SMITH; MARY TIDWELL

Arch Neurol. 1965;13(3):238-262.

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A GENETIC strain of ataxia was isolated from rabbits by Sawin and reported upon in detail by Sawin, et al.¹ Anders² described the histopathology of the brainstem lesions and this report was later amplified by O'Leary, et al³ in this journal. The condition results from the action of a lethal single recessive mutant gene. In the affected members of a litter, clinical manifestations and the characteristic lesions appear at adolescence so that with sufficient material it is possible to evaluate the chronology of lesions and relate their distribution and severity to the clinical state of the animal. Between the earlier and later pathological report (17 years), many generations of the strain intervening, the natural history became so altered that instead of the affected animals pursuing a fulminating course to death in two to three weeks, a significant number lived much longer. Thus, this later report provides a . . . [Full Text PDF of this Article]

Author Affiliations
ST. LOUIS

From the Beaumont May Institute of Neurology and the departments of neurology and neurosurgery, Washington University School of Medicine, St. Louis.

Footnotes
Submitted for publication April 27, 1965; accepted April 28.

Reprint requests to 666 S Euclid, St. Louis, Mo 63110 (Dr. O'Leary).

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