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The Relation of Focal to Diffuse Epileptiform EEG Discharges in Genetic Epilepsy
PATRICK F. BRAY, MD;
W. C. WISER, MS
Arch Neurol. 1965;13(3):223-237.
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A CROSS-SECTIONAL, controlled study of 40 families, one member each of which presented with focal "temporal lobe" epilepsy, has been described.1 The type of EEG abnormality present in the probands was also seen in a close relative in 30% of these families. Similar electroencephalographic abnormalities were seen in 36% of siblings and children of probands (compared to 2% in the control group) and in 19% of parents of probands (compared to 2% in the control group). Analysis of the genetic characteristics of this electroclinical trait suggests that the disorder is transmitted by one or more autosomal dominant genes (ie, either it is caused by a single dominant gene with variable penetrance, or it is a polygenic trait).2 Gene penetrance of this trait (as measured by the electroencephalogram) is low in early childhood (14% between birth and five years of age), reaches a peak in middle childhood (56% between
. . . [Full Text PDF of this Article]
Author Affiliations
SALT LAKE CITY
From the Department of Pediatrics and the Division of Neurology, College of Medicine, and the Department of Genetics and Cytology, University of Utah. Associate Professor of Pediatrics and Neurology, College of Medicine (Dr. Bray), Predoctoral Student, Department of Genetics and Cytology (Mr. Wiser).
Footnotes
Submitted for publication Feb 23, 1965; accepted March 20.
Read before the meetings of the American Neurological Association and the Society for Pediatric Research, June 1964.
Reprint requests to University of Utah Medical Center, Salt Lake City, Utah 84112 (Dr. Bray).
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