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Early Histological and Electro physiological Alterations in Peripheral Nerves

ALBERT BEHAR, MD; ELIEZER RACHMILEWITZ, MD; RAMI RAHAMIMOFF, MD; MICHAEL DENMAN, MB, MRCP

Arch Neurol. 1965;13(2):160-163.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

SINCE the introduction of nitrofurantoin (NF) in the treatment of urinary tract infections, in 1953, some 35 cases have been reported in which this drug has, in the recommended doses, caused peripheral polyneuropathy, occasionally resulting in irreversible paralysis.^1-20 As nitrofurantoin is mainly excreted through the kidney, abnormally high plasma drug levels resulting from impaired renal function might be considered a causative factor in the production of polyneuropathy. Thus Loughridge¹⁰ reported that in a patient suffering from nitrofurantoin polyneuropathy and renal insufficiency, plasma drug levels were as high as 6.5µg/ml. She also found raised plasma nitrofurantoin levels in 13 patients with various degrees of renal impairment, who were similarly treated with daily doses of 300 mg of the drug. On the other hand, plasma nitrofurantoin levels in subjects with normal renal functions were found to have a mean value of 1.8µg/ml¹⁰ and 2.23µg/ml.²²

The aim of the . . . [Full Text PDF of this Article]

Author Affiliations
JERUSALEM, ISRAEL

From the Department of Pathology (Laboratory of Neuropathology), the Department of Internal Medicine "B" (Laboratory of Hematology), and the Department of Physiology, the Hebrew University, Hadassah Medical School and the Rothschild Hadassah University Hospital.

Footnotes
Submitted for publication March 8, 1965; accepted March. 20.

Reprint requests to Hebrew University, Hadassah Medical School, Jerusalem (Dr. Behar).

Urantoin, manufactured by the RAFA Pharmaceutical Co. Jerusalem, Israel.

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