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ROBERT H. WILKINS, MD; GUY L. ODOM, MD

Arch Neurol. 1965;13(2):149-154.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

METHOD of producing intracranial neoplasms in rats, rabbits, cats, or dogs would be a very useful adjunct to the study of human brain tumors. These animals are readily available and inexpensive, and such a method could be employed in the preliminary testing of diagnostic and therapeutic techniques, thus avoiding the use of human patients for these purposes.

Spontaneous intracranial neoplasms are uncommon in animals.^1-12 Furthermore, although neoplasms originating in tissues outside the nervous system of the host can be transplanted intracerebrally in several species of animals,^12-24 the difference between these tumors and primary gliomas limits their value as experimental models.

Primary gliomas can be induced consistently in mice by the intracerebral insertion of carcinogens,^12,25,26 and occasionally in rats by the intracerebral insertion^12,25,27-32 or oral administration^33-35 of similar chemical agents. Also, tumors resembling ependymomas can be induced in hamsters by the intracerebral injection of simian virus . . . [Full Text PDF of this Article]

Author Affiliations
DURHAM, NC

From the Division of Neurosurgery, Duke University Medical Center, Durham, NC.

Footnotes
Submitted for publication Jan 26, 1965; accepted March 20.

Reprint requests to Division of Neurosurgery, Duke University Medical Center (Dr. Wilkins).

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