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Biochemical and Pathological Correlation

MELVIN GREER, MD; AARON H. ANTON, PhD; CLYDE M. WILLIAMS, MD; PhD; RENE A. ECHEVARRIA, MD

Arch Neurol. 1965;13(2):139-148.

	Since this article does not have an abstract, we have provided the first 150 words of the full text PDF and any section headings.

DIAGNOSIS of tumors of neural crest origin—neuroblastoma, ganglioneuroma, ganglioneuroblastoma, and pheochromocytoma— has been aided by biochemical tests which measure increased urinary excretion of certain metabolites of the naturally occurring catecholamines: norepinephrine (NE), epinephrine (E), dopamine (DM) and dopa (DA).^1-13 This provides rapid identification of the general tumor type preoperatively and offers a laboratory guide for evaluating the efficacy of treatment. Chemical analyses of tumor tissue^2,5,14-19 as well as electron microscopy^19,20 have provided additional information concerning the secretory nature of these tumors.

These studies evolved from a recognition of the embryological relationship between these tumors and other known catechol-producing tissues: the adrenal medulla, sympathetic nerves, and ganglia. The adrenergic mediator, 1-norepinephrine, is produced in sympathetic nervous tissue following a well-defined chemical sequence starting with tyrosine (Fig 1). In the adrenal medulla, the identical chemical transformation takes place, following which NE may be methylated to 1-epinephrine. These two . . . [Full Text PDF of this Article]

Author Affiliations
GAINESVILLE, FLA

From the Departments of Medicine (Neurology), Radiology, Anesthesiology, and Pathology of the University of Florida College of Medicine. Associate Professor of Medicine and Pediatrics (Dr. Greer); Assistant Professor of Surgery and Pharmacology (Dr. Anton); Professor of Radiology (Dr. Williams); Resident in Pathology (Dr. Echevarria).

Footnotes
Submitted for publication March 3, 1965; accepted March 20.

To be read by title before the Annual Meeting of the American Neurological Association, Atlantic City, NJ, 1965, and submitted as thesis for membership.

Reprint requests to University of Florida Medical Center, Department of Medicine, Gainesville, Fla 32603 (Dr. Greer).

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